Skin· May 24, 2026 · 8 min read
Polynucleotides for skin rejuvenation: mechanism, evidence, and comparisons
Polynucleotide injectables use purified DNA fragments to stimulate fibroblasts and rebuild the extracellular matrix.
Topic
Biostimulators
Sculptra, Radiesse, Bellafill, PDO threads, PDRN, exosomes. Collagen-stimulating injectables that work over weeks to months, not minutes.
Skin· May 24, 2026 · 9 min read
Profhilo bioremodelling: how it works, what the evidence says, and who it fits
Profhilo is an injectable hyaluronic acid bioremodeller that stimulates collagen and elastin without adding volume.
Injectables· May 23, 2026 · 11 min read
Sculptra vs filler: collagen stimulation vs instant volume, and when each makes sense
Sculptra (PLLA) stimulates your own collagen over months, lasting up to 2 years. Hyaluronic acid fillers add immediate volume for 6–18 months and can be dissolved.
Providers· May 22, 2026 · 11 min read
GLP-1 Facial Volume Consult Protocol: Timing and Referral Boundaries
A consult framework for GLP-1 facial volume loss, including weight stability, staged filler or biostimulator plans, overcorrection risk, and surgical referral boundaries.
Injectables· May 17, 2026 · 10 min read
Will Filler Affect a Future Facelift? What Surgeons See and What Patients Should Ask
Filler usually does not prevent a facelift, but years of injections can affect surgical planning. Learn which fillers matter and what to ask before surgery.
Injectables· May 15, 2026 · 10 min read
Sculptra vs Radiesse: PLLA vs CaHA biostimulators compared
Sculptra (PLLA) and Radiesse (CaHA) are both collagen-stimulating injectables but differ in mechanism, onset, sessions, longevity, and reversibility. Here is how they…
Ran Chen#Biostimulators#Dermal Fillers
Injectables· May 14, 2026 · 9 min read
Rejuran vs Skinvive: skin boosters that do completely different things
Rejuran uses salmon DNA polynucleotides to repair skin. Skinvive uses hyaluronic acid microdroplets to hydrate it. One is FDA-approved in the US. The other is not.
Injectables· May 13, 2026 · 12 min read
Biostimulators vs HA fillers: collagen, reversibility, and patient fit.
HA fillers give instant volume and can be dissolved. Biostimulators build collagen over months but cannot be reversed. How to choose, evidence on complications, and why…
Ran Chen#Dermal Fillers#Biostimulators
Injectables· May 13, 2026 · 12 min read
GLP-1 facial volume loss: fillers, Sculptra, fat grafting, or skin tightening?
Ozempic face is real — but not everyone needs the same fix. A staged comparison of HA fillers, Sculptra, fat grafting, energy devices, and surgery for GLP-1-related…